ThermoLife International’s E-BOL
is a natural and non-hormonal dietary supplement designed to boost anabolism, recovery, and endurance (among many other things). It has a huge number of other health benefits aside from these, and nearly every positive effect is shown across multiple ingredients. The precision blend of 7 carefully selected ingredients has been painstakingly researched to provide maximum health benefits completely naturally, with no side effects. Below are detailed descriptions of each of the 7 ingredients in E-BOL with outlines of what they do, and with each claim made backed up by scientific research.Ecdysterone (from Rhaponticum Carthamoides):
Ecdysterone is a hormone present in plants and insects and has a typical steroidal chemical structure. Its effects in humans are drastically different than they are in plants meaning that it is non-hormonal in humans and has none of the typical side effects associated anabolic steroids (a completely different class of hormone molecules). It has been touted as ‘the Russian Anabolic Secret’ and has been shown in many studies to increase anabolism and muscle growth as well as endurance (drastically). One key thing to keep in mind when looking at an ecdysterone based supplement is the plant source from which it was extracted. ThermoLife uses ultra high purity extracts specifically sourced from the Rhaponticum carthamoides plant and standardized for 99% ecdysterone, the purest ecdysterone extract in the entire in the world.
When looking at any product containing ecdysterone it is important to know that any and all studies showing anabolic activity from ecdysterone used extracts from Rhaponticum Carthamoides plants, the same material used by ThermoLife. These studies observed steroidal like increases in anabolism and erythropoiesis (red blood cell differentiation) similar to the popular drug nerobol (D-BOL) but without the androgenic effects (1,2,3). Many other studies have been done on ecdysterone and Rhaponticum carthamoides, and effects such as (4) increased endurance (perhaps due to their ability to increase red blood cell production), (5) strong antioxidant activities, (6) hypolipidemic effects (cholesterol lowering), and (7) anti-microbial effects have been widely observed. Ecdysterone supplementation in quails (8), mice (9) and pigs (10) has shown remarkable increases in muscle growth, protein synthesis, and greatly increased quality of animal products. These effects have been seen on numerous different animals in many different medical studies, as well as in humans. A study done on humans showed significant increases in anabolism, as well as fat loss (11). Although the action of these molecules is hormonal in plants (through different biological pathways than in humans), it is not directly so in humans and therefore is considered completely natural and non-hormonal. A proposed mechanism for the anabolic actions of ecdysterone in the body is by means of (12) increasing protein synthesis. It is suggested that this is due to (12) increased ribosome activity and increased speed of assembly of ribosomal subunits into translation complexes (i.e. 80s initiation complex) which synthesize proteins using mRNA (messenger RNA are instructions for protein assembly) as a template. It is also suggested that through this increased ribosomal activity, the speed at which polyribosome units translocate amino acids onto growing polypeptide chains is increased; these combined effects yield overall increased rates of protein synthesis. Another study which demonstrated these effects showed that supplementation with ecdysterone can cause increases in protein synthesis in the liver by as much as 50% (13).
Unlike anabolic steroids, which are typically required to promote the sort of anabolic improvements and effects that been previously discussed, ecdysterone does not have any negative impacts on the body’s functions. The effects are quite opposite to the negative sides of anabolic steroids, and studies have shown it to protect liver function (14,15), and scavenge free radicals (5). It has also been suggested that on top of being infinitely safer than the anabolic steroid nerobol (and all anabolic steroids for that matter), it may actually have (4) a wider range of actions and may cause greater increases in endurance in a shorter period of time. The range of positive effects from this compound seem to be endless, and it even has the effects of increasing sexual performance in human males (17), increasing learning and memory in rats (18), and lowering blood pressure (anti-hypertensive) (19).Radix Cyathulae (20% Cyasterone):
Radix Cyathulae is a traditional Chinese plant that has been used for centuries to aid in blood stagnation, improve liver and kidney functions, alleviate depressive moods, and help with joint pains. Along with containing the exciting compound ecdysterone (as discussed above), it contains 10 other potent plant sterols with very strong promise for anabolic activity. Among these 10 new ecdysteroids, the most exciting addition is cyasterone. It is a molecule which has similar structural properties to ecdysterone and exhibits many (perhaps more) of the same benefits. The key difference here is that Cyasterone has (20) anabolic effects even greater than those of ecdysterone, and is comparable in this sense to another less known but very potent plant sterol, turkesterone. In order the maximize the anabolic effects of cyasterone, the Radix Cyathulae extract used by ThermoLife International in E-BOL is standardized to at least 80% ecdysteroids. This yields 20% of the total extract being cyasterone and the other 60% being made up of the following 10 additional plant sterols:
The anabolic effects of ecdysterone are well studied and it has been shown to be potent enough to be used as its own highly anabolic supplement (i.e. ThermoLife Ecdysten and the Russian drug Ecdysten). The other components listed above on their own have great potential for anabolic activity; however this has yet to be fully studied. Anecdotal evidence suggests that the inclusion of these additional plant sterols provides massively increased synergy and yields unprecedented anabolic activity. The synergy that occurs in the full plant extract as opposed to a single isolated sterol is very powerful and greatly improves all of the positive effects of these compounds (all benefits listed about ecdysterone). These new plant sterols combined with the already well known activities of ecdysterone and the even greater anabolic properties of cyasterone packs a very powerful anabolic punch. The strong effects of these ecdysteroids are not just for muscle growth, and they have been shown to yield impressive increases in endurance, as well as memory and learning (21). These findings indicate that supplementation of plant sterols are not just for bodybuilders (although ideal) and are beneficial for all athletes regardless of their specific sport. The effects seen from Radix Cyathulae are very similar to those listed for ecdysterone (see the section on Ecdysterone for details of effects), such as increased anabolism and muscle growth (16), as well as liver protective effects (3) and neuro-protective effects (22).
The antioxidant properties of ThermoLife International’s exclusive Radix Cyathulae extract are very powerful because it has the ability to (23) increase the activity of the enzymes superoxide dismutase and catalase. The reason why this is so profound is because typical free radical scavengers must intercept and neutralize free radicals, which is a second order reaction requiring the chance collision of two molecules. This reaction relies on the probability of two incredibly small molecules spontaneously colliding (not fantastic odds, and is somewhat concentration dependant), which reduces the overall efficiency and frequency of the reaction. Antioxidant activity acting through an enzyme however has exponentially higher effectiveness and has a cascading ability to work much faster and more efficiently. Superoxide dismutase (SOD) is the enzyme responsible for neutralizing superoxide anion radicals, and catalase is responsible for neutralizing hydrogen peroxide (both are very reactive and harmful oxygen species). The high affinity of these reactive oxygen species for the active sites of the SOD and catalase enzymes, the extremely fast turnaround time of the enzymes, and their high abundance gives them extremely high antioxidant activities. These harmful reactive oxygen species are very common by-products of many of the human body’s regular metabolic pathways. This means that effective neutralization of these dangerous oxygen radicals is crucial for the survival and optimal function of our cellular machinery. This does not mean that your regular antioxidants such as vitamin C and green tea are obsolete, because SOD and catalase are specific to reactive oxygen species and do not hunt for regular free radicals. Many of the plant ecdysteroids (as well as other ingredients in E-BOL) however also work by conventional free radical scavenging methods and are effective against other types of potentially hazardous free radical molecules. The blend of ecdysteroids from Radix Cyathulae and Rhaponticum carthamoides, combined with the strong antioxidant abilities of many of the other ingredients in E-BOL makes it quite literally a super antioxidant formula. An example of some of the intense synergy in this formula is that both Ashwagandha and 6-Methyluracil have similar antioxidant effects as Radix Cyathulae and show strong superoxide dismutase and catalase boosting capabilities.
Like the ecdysterone used in E-BOL the Rhodiola Rosea used in E-BOL is the most potent extract in the entire world standardized to a previously unheard of 15% rosavins (typical extracts contain 3% rosavins) and 5.1% salidrosides.
Rhodiola Rosea belongs to the plant family Crassulaceae, and grows mostly in high altitude locations in the arctic areas of Europe and Asian. It has been used for centuries in traditional medicine to help improve physical endurance, work productivity, longevity, resistance to high altitude sickness, depression, anemia, impotence, gastrointestinal ailments, infections, and nervous system disorders. In recent scientific studies on Rhodiola Rosea it has been shown that many of these properties are not just folk lore, and the effects are indeed quite potent.
It has been classified as a plant adaptogen, which means that it increases the ability of an organism to adapt to mental and physical stress. The increased ability of an organism to adapt to environmental factors and avoid being harmed by them allows for steady physical and mental improvement. Rhodiola has been shown to (24) increase mental performance and physical work capacity while yielding no addictive properties or any sort of an energy crash. Rhodiola is believed to have potential at treating mental disorders such as Alzheimer’s due to its mental and memory enhancing abilities. It is proposed that these effects are due to (25) the ability of rhodiola to act as acetylcholine esterase inhibitor (ACE inhibitor), which decreases the breakdown of the neurotransmitter acetylcholine. It has also been shown that (26) Rhodiola can stimulant central nervous system function (CNS) and reduce depression-type behaviors and symptoms. The effects of increasing mental capacity and energy are also coupled with (26) strong protective effects against neurotoxicity which will help maintain mental functions and help ward off disorders such as Alzheimer’s. Another fantastic health benefit that Rhodiola Rosea has is its (27) anti-diabetic and blood sugar regulating effects (it shows clear anti-hyperglycaemic and insulin stimulating activity). The benefits from this plant are not limited to the mind and it has been shown to be (28) hepatoprotective and help to normalize liver enzymes. In a double blind study performed on medical physicians working stressful night shifts, Rhodiola was shown to (29) improve fatigue resistance and reduce general fatigue. In another double blind study performed on stressed out students during an exam period, Rhodiola was shown to (30) yield significant improvements in physical fitness, mental fatigue, and neuro-motoric tests. Test subjects also experienced enhanced mood and feelings and well being. On top of all of this Rhodiola has been shown to (31,32) have strong anti-mutagenic effects (prevents occurrence of genetic mutations which can possibly lead to health problems). Similar to many of the other ingredients in E-BOL, Rhodiola also has (34) potent hypolipidermic effects (decreases cholesterol), as well as (35) protective effects on the heart. The most exciting benefits of Rhodiola Rosea (and least known) are its anabolic properties. Every ingredient in E-BOL has been shown in studies to exhibit anabolic properties (among many other great effects), and Rhodiola is no different. Studies suggest that Rhodiola may exhibit (36) great anabolic properties in animals, perhaps through increasing protein/amino acid synthesis, ribonucleic acid (RNA) transcription, ATP concentrations of cells (and hence increasing metabolism), and ammonia reassimilation. Rhodiola has also been shown to greatly increase fat loss by increasing fat metabolism (37).
The most active compounds present in Rhodiola Rosea, which are responsible for these effects are the rosavins and salidrosides. The extract of Rhodiola used in E-BOL is the most potent extract currently available in the word, being standardized to an impressive 15% rosavins (typical extracts contain 3% rosavins) and 5.1% salidrosides. All of these effects provide great synergy with the other ingredients in E-BOL and have the effects of increasing recovery, athletic performance, and health.
Ionol is a potent synthetic antioxidant, which has been used as a food additive for years with the purpose of prolonging the life of goods and providing extra health benefits to the consumer. Ionol has been shown to be a strong antioxidant having health benefits such as (38) boosting immune system function, (38) helping to prevent viral infections, and also (39) participating in mitochondrial membrane protection (the mitochondria is the main site of aerobic respiration in the body). The preservation and antioxidant effects of ionol (also known as BHT) are very well known, however the potent anabolic effects that occur at a correct dosage are not nearly as well known. It has been shown that (40) supplementation of ionol yielded increased DNA and protein synthesis in mouse organs in 2-4 and 1.2-1.5 times, respectively. These significant increases are coupled with the effects it has on (41) reducing the amount of corticosterone released from the adrenal glands during emotional-painful stress (i.e.: physical activity). Corticosterone is a catabolic hormone, and therefore suppressing its release during exercise will yield greater muscle growth potential and have an anti-catabolic effect (will prevent the breakdown of existing muscle tissue). Another study on ionol shows that it (42) not only increases protein synthesis, but also increases the rate of DNA repair. The anabolic potency of E-BOL is exponentially increased by the synergy occurring between all 7 anabolic ingredients.
6-Methyluracil (6MU) is a nucleoside analog which is nearly identical to the base uracil, with the exception of a methyl group on the number 6 carbon position. 6MU is very close in molecular structure to both uracil and thymine (thymine is merely 5-Methyluracil). Nucleosides are part of what make up our DNA bases, and are one of several of the building blocks of DNA (similarly to how amino acids are the building blocks of proteins). 6MU has been shown to (43) accelerate healing from burn wounds; with the proposed mechanism for this being the involvement of 6MU in the regulation of lipid peroxidation processes. Although this study was specific to burn wounds, the underlying mechanism for increased healing occurs even in the absence of burn wounds. This means that the increased healing and repair shown in the burn wound study should be effective on other sorts of traumas (all sorts of repairs such as muscle repair and general bodily healing). The underlying mechanism is the regulation of lipid peroxidation, which has been shown (44) to occur in mice livers (mice which did not have burn wounds). This further supports the anecdotal feedback that 6MU does indeed increase healing and repair in subjects that were not exposed to traumas such as burn wounds. The increased lipid antioxidative activity caused by 6MU as mentioned above helps to protect lipids from degradation by radicals. Lipid peroxidation is the process by which lipids are destroyed via oxidation (loss of electrons) by free radical species such as ROS (reactive oxygen species such as superoxide anion, hydrogen peroxide, hydroxyl radicals, etc…). Lipids (fats) are not just used for storing energy and have a wide range of effects in the body such as helping to make up cell membranes and acting as transport molecules. These ROS were previously discussed and shown to be greatly reduced by antioxidants that stimulate superoxide dismutase and catalase, such as radix cyathulae, and ashwagandha. 6MU’s effects of increasing the healing process of the body are further reinforced in a study (45) which also shows that 6MU has influence on lipid peroxidation regulation, as well as having antioxidant capabilities by increasing superoxide dismutase (SOD) activity. It has been suggested (46) that these lipid antioxidative effects from 6MU are most active in muscle tissues, which is where a large amount of stress and damage occurs during exercise. The previous two studies were not done on burn victims, which further support the ability of 6MU to increase the rate of healing and repair in the body. The ability of 6MU to speed up the process of repair and healing in the body has profound implications on its ability to improve recovery and subsequently improve muscle growth after weight training and exercise. The effects of 6MU are not just increased healing through lipid peroxidation regulation. It has been shown (47) to increase survival times of mice which were injected with the poison TEM or bombarded by x-rays, showing an overall anabolic effect. In another study (48) it is possibly shown that the anabolic properties of 6MU are through increased protein synthesis and anti-catabolic effects. All of these effects greatly add to the already impressive abilities of E-BOL to help increase anabolism and protein synthesis, decrease damage by free radical species, and increase the healing and recovery processes of the body through numerous different pathways.
Ashwagandha (Withania somnifera) is a herb that is extensively used in Ayurveda, the traditional health care system in India as a general tonic and adaptogen. Interestingly enough the name comes from the peculiar odor that the plant gives off, which has been compared to that of a sweaty horse (just for the record your container of E-BOL will not smell like a sweaty horse). The most active components in ashwagandha are withanolides and ThermoLife uses an extract that is standardized to a very potent 1.5% withanolides. Supplementation with Ashwagandha in mice has been shown to (49) yield increases in superoxide dismutase (SOD, a potent antioxidant enzyme which destroys superoxide anion radicals), glutathione (the body’s ‘master’ antioxidant, extremely important in immune function and healing), and yield decreases in DNA damage (anti-mutagenic). Another study (50) also supports the fact that supplementation with Ashwagandha increases levels of SOD, as well as the enzyme catalase (also an antioxidant enzyme which quenches hydrogen peroxide) in humans. The antioxidant power of supplementing with SOD and catalase boosting compounds (such as Ashwagandha, Radix Cyathulae, and 6MU in E-BOL) is far greater than that of typical antioxidants such as vitamin C or vitamin E (46). Another pathway (in addition to increasing SOD and catalase activity) that has been proposed for the immunostimulatory effects of Ashwagandha is the increased production of (51) NO (nitric oxide), especially in macrophages (responsible for destroying and presenting foreign organisms/particles to antibodies). Ashwagandha has also been shown in part to (52) increase levels of the thyroid hormones thyroxine (T4) and triiodothyronine (T3) in mice, without causing any changes in hepatic lipid peroxidation (no adverse effects on the liver); it was also shown to increase catalase activity (liver protective). Due to these thyroid hormone boosting abilities it has been suggested as an aid for treating hypothyroidism (52) as well as a good fat loss aid and metabolic enhancer (with no thyroid suppression). These findings would indicate that E-BOL stacked with ThermoLife Dicana would be an excellent stack for fat loss, with the extra anti-catabolic, anabolic, and healing properties of E-BOL helping a great deal towards the overall effects. Another study (53) supports these findings and shows Ashwagandha supplementation to increase T4 and T3 concentrations as well as show very strong liver protective effects by decreasing lipid peroxidation and increasing SOD and catalase activity. There is very strong synergy shown between the many ingredients (many shared positive effects between ingredients) in E-BOL which further increase the activity of these enzymes and decreases lipid peroxidation, subsequently showing amazing increases in recovery and general health. The individual ingredients Ashwagandha, Radix Cyathulae, and 6MU have all been shown to be very effective at doing these things on their own, and when combined together they are an anabolic and antioxidative healing force to be reckoned with. In frogs and mice ashwagandha has been shown to (54) yield cardio-protective and adaptogenic effects as well as increases in tissue weights (potentially anabolic), and increased swimming performance.
All of the ingredients in E-BOL so far have had strong anabolic properties and Ashwagandha is no different, showing amazing potential for increased anabolism and muscle growth. In a study performed on mice (55), administration of ashwagandha showed significant increases in swimming times and bodyweights, displaying fantastic anabolic potential. To perfectly aid and enhance these anabolic effects, in mice Ashwagandha has been shown to (56) increase red blood cell, white blood cell, and platelet counts. Increases in these cells may yield immunostimulatory effects (improved immune system function), improved oxygen delivery, increased physical endurance, and improved recovery. This same study also shows direct anabolic effects by means of significantly increased body weights. These effects are made even more profound due to the fact that there are no negative side effects, and there are actually countless positive health effects and absolutely no loss of gains or rebound effects (as with steroids). The very powerful liver and kidney protecting/healing effects (57) of Ashwagandha are especially relevant to bodybuilders due to increased caloric intakes. The large protein intake of bodybuilders places a greater work load on the renal system of the body; not to mention the potentially increased number of vitamins/supplements/compounds which are ingested and need to be processed and metabolized. Ashwagandha also has extraordinary antioxidant effects (boosting SOD, catalase, decreasing lipid peroxidation) (58), anti-ulcer effects (58), neuro-protective/memory enhancing effects (59), and chemo-protective effects (60,61). The strong adaptogenic abilities of Ashwagandha make it a great addition to the other adapotgens present in E-BOL, and shows great anti-stress (62,63), cardio-protective (64), and even anti-inflammatory effects (65).
Due to Ashwagandha being such an amazing plant and having effects such as; anti-inflammatory, anti-tumor, anti-stress, antioxidant, immunomodulatory, hemopoietic, and rejuvenating properties, it has been recommended that clinical trials for a number of health conditions be conducted with it (66).
6-KETO diosgenin ((25 R)-5alpha-spirostan-2alpha, 3beta, 5alpha-triol-6-OH): 6-KETO diosgenin is a natural derivative of a class of compounds called sapogenins. Similar to ecdysterone, sapogenins are plant sterols (plant hormones) which among exhibiting many other positive health benefits, show potent anabolic properties and have no negative side effects. 6-KETO diosgenin has been shown in rats to (67) have very prominent anabolic effects with no change in testicular or prostate weight and no changes in genitalia (and no androgenic effects). The increased anabolism and growth in subjects receiving 6-keto diosgenin was almost 2 times as high as the control group, yielding astounding anabolic potential. This compound is custom made and world exclusive to ThermoLife International, and due to this fact the amount of information on it is limited. The findings in the above study, combined with the overwhelming positive anecdotal feedback however are extremely promising. Its addition to E-BOL plays a key role in its amazing synergistic effects and takes its anabolic growth potentials to the next level.
A note on synergy: Tying it all together: If the previous 67 peer reviewed scientific/medical studies (which clearly showed the incredible benefits and ‘teamwork’ of all of the ingredients in E-BOL) were not enough to convince you that ThermoLife E-BOL is indeed the most ground breaking non-hormonal supplement to ever be released, then perhaps an overview of the benefits will hit the point home. It’s important to emphasize that the potent anabolic synergy (as well as antioxidant, hypolipidermic, recovery, etc…) in all of E-BOLS ingredients are completely natural and safe, with no negative side effects such as those commonly experienced with steroids. The profound impact of this fact may take a minute to really ‘sink in’, because there is really no suppression or alteration in natural testosterone production with none of the common steroid side effects. To have anabolic effects of the nature and size seen in E-BOL (and proven in medical studies) with absolutely no introduction/augmentation of human hormone levels (such as testosterone, DHT, etc…), and with no androgenic effects is basically unheard of. Many of the ingredients also show very powerful liver healing abilities, strong antioxidant effects (and subsequently anti-aging abilities), immune system boosting effects, anti-mutagenic activity, increased recovery and healing effects, and many more. Anabolic steroids are illegal and have a huge number of potentially deadly side effects; E-BOL however aids and improves an astounding number of functions in the human body yielding incredible health benefits. Every one of the 7 ingredients in E-BOL show powerful non-hormonal anabolic properties; many of which are through different pathways which provide great synergy (teamwork) to maximize growth. These extremely potent anabolic effects have absolutely no negative health effects such as anabolic steroids, and have exactly the opposite effects which are proven by the large number of studies claiming amazing positive results. The adaptogenic effects of E-BOL from Rhodiola Rosea and Ashwagandha provide increased adaptability to mental/physical stresses (exercise is a key example of this, as well as other daily stress’s) have endurance/performance enhancing effects as well as increased recovery and (which all greatly aid muscle growth). Just to emphasize the great benefits of the precision blend of ingredients in E-BOL, the following list shows all of the positive health effects outlined so far.
Increased rates of erythropoiesis (red blood cell differentiation)
Increased white blood cell and platelet production
Increased anabolism with no adverse health effects or androgenic effects
Increased endurance and physical performance/work capacity
Strong free radical scavenging abilities (antioxidant effects)
Strong superoxide dismutase and catalase boosting abilities (antioxidant effects)
Hypolipidermic effects (Cholesterol lowering)
Anti-diabetic blood sugar moderating abilities
Increased rates of protein synthesis
Increased rates of fat loss and fat metabolism
Hepatoprotective effects (Protecting liver/kidney function as well as aiding in repair of damage)
Improved sexual performance
Anti-hypertensive effects (blood pressure lowering)
Improved memory and learning capabilities
Neuro-protective effects (helps against neurodegenerative diseases)
Alleviation of depression symptoms/mood elevation
Adaptogenic abilities (improves ability to adapt to physical/mental stresses)
Improved fatigue resistance
Aiding in mitochondrial membrane stabilization (main site of energy metabolism)
Stimulation of the immune system
Helping to prevent viral infections
Decreased amount of corticosterone released (catabolic hormone)
Increased rates of healing/recovery
Improved lipid peroxidation regulation
Increased levels of thyroid hormones T3 and T4
Mild Anti-inflammatory effects
Now try and find another product (dietary supplement or even pharmaceutical drug for that matter) that even claims to have as many health benefits as this (with no side effects), let alone provides 67 scientific studies proving them to be true. It’s very easy to make unfounded claims and provide hype to sell a product, however providing the cold hard facts with medical/scientific studies is something ThermoLife International pride’s itself on. Welcome to ThermoLife’s non-hormonal anabolic revolution, officially sponsored by science and research.
Serving Size: 2 Capsules
Servings per Container: 90
Amount per Serving: Ecdysterone (99% pure Ecdysterone extracted from Rhaponticum carthamoides) 80 mg Radix Cyathulae (20% Cyasterone) 100 mg Rhodiola Rosea (15% rosavins, 5.1% Salidrosides ) 41.66 mg Ashwhaghanda (1.5% withanolides) 277.6 mg Ionol 83.33 mg Super 6 Anabolic Cocktail ™ (patent pending proprietary formula) 187.88 mg
6-Methyluracil (6-mu) 6-keto diosgenin (100%)
As an adult dietary supplement take two capsules 3 times per day. For best results it is recommended to increase your protein intake while using this product.